Senior Research Fellow AbbVie Inc. Irvine, California
Objectives: 1. Highlight the Importance of In vitro Models: Emphasize the critical role that in vitro translational models play in the early stages of mRNA LNP development, providing insights into gene expression and safety. 2. Examine Current Challenges: Discuss the prevailing immunogenicity challenges 3. Present Case Studies: Showcase specific case studies of predictive tools to assess immunogenicity risk for mRNA-LNP projects, illustrating the successes and limitations experienced when utilizing in vitro models. 4. Strategies for Improvement: Propose strategies that can be employed to improve the predictability and reliability of in vitro models.
Learning Objectives:
Upon completion,participant will be able to emphasize the critical role of in vitro translational models play in the early stages of mRNA LNP development, providing insights into safety.
Upon completion participants will be able to discuss the prevailing challenges in using in vitro models, including the translation of results to potential safety impact.
Upon completion, participant will be able to gain insights into the successes and limitations of in vitro models and understand the utility of innovative strategies and technologies.
