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From Bench to Bedside: Bioanalysis and Translational Science

Using Organ-on-a-Chip Technology to Model CAR-T Cell Therapies and Bi-Specific Antibodies

Wednesday, May 7, 2025
10:30 AM - 11:00 AM ET
Location: Stone
Bench to Bedside
1. Using organ-on-a-chip technology to model CAR-T cell therapies and bi-specific antibodies (15 minutes)
o Holistic organ-on-a-chip model to assess recruitment, target-specific efficacy and fitness of CAR-T cell therapies
o Modeling cytokine release syndrome in vitro

Learning Objectives:

  • Discuss cutting-edge developments in applying microphysiological systems (aka organ-on-a-chip) to develop CAR-T therapies.
  • Discuss the benefitis of assessing CAR T cell recruitment, migration and fitness using a dynamic in vitro model using microfluidics.
  • To foster collaboration between computational biologists, pharmacologists, and clinical researchers.