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From Bench to Bedside: Bioanalysis and Translational Science

PK & ADA Bioanalysis Support for ARCs/siRNA: Case Studies

Monday, May 5, 2025
11:15 AM - 12:00 PM ET
Location: Learning Lab in the Grand Ballroom

Sponsored By 
Bench to Bedside Partner Presentation
Description: Bioanalysis for support of next generation Antibody siRNA Conjugates (ARCs) have exploded recently. Several case studies will be shown that highlight the PK, Immunogenicity, and PD/BM bioanalytical approaches for ARCs and siRNA using QqQ, HRMS, Molecular, and hybrid ELISA . A novel 1.5 plex ARC assay will be presented to detect total antibody and antisense & total antisense and a novel ADA bridging assay.

Learning Objectives:

  • Understanding the options for PK, Immunogenicity, and PD/BM Bioanalysis of ARCs/Oligos
  • Understand the bioanalytical challenges associated with antibody siRNA conjugates (ARCs)
  • Understand the different strategies for developing "Oligonucleotide assays" - based on Modality – ARC/siRNA/ASO, QqQ vs HRMS, Immunogenicity (ADA)